My Current Longevity Stack

The speaker reflects on the evolution of the quantified self-movement from a small gathering in 2008 to a vast community of biohackers focused on longevity. While acknowledging "a lot of nonsense," the speaker shares personal interventions, emphasizing foundational practices like sufficient sleep, regular exercise, and healthy eating. The speaker notes that only a few supplements, specifically Vitamin D and creatine, seem consistently helpful. There's also an interest in future "real drugs" that could address specific aging issues, such as eye drops for weakening eye muscles, or cosmetic applications like peptides. The other speaker, described as more conservative, recalls early experiments with technologies like continuous glucose monitors. This speaker generally adheres to a "no biological free lunch" heuristic, which helps avoid many pitfalls. Current experiments include different forms of ketone esters and salts, particularly for cerebral vascular health, given a family history of Alzheimer's and Parkinson's. Rapamycin is considered interesting but requires extreme caution due to its immunosuppressant properties. A potential experiment involves combining Norwegian 4x4 interval training with rapamycin pulsing to observe volumetric changes in the hippocampus. Beyond these, the speaker maintains a basic regimen of creatine and Vitamin D, along with monitoring magnesium if taking medications like omeprazole. Urolithin A and intermittent fasting, including occasional 3 to 7-day fasts or fast-mimicking diets, are also mentioned for mitochondrial health and fostering autophagy. The conversation then explores the concept of "rebooting" the body. While anesthesia is discussed with caution due to poorly understood mechanisms and potential cognitive side effects, the speaker highlights ibogaine as a powerful "reboot" for specific cases, particularly opiate addiction. Ibogaine, though dangerous and requiring medical supervision, can offer a window free of withdrawal symptoms and has even shown some evidence of "reversal in brain age" in studies on veterans with traumatic brain injury. Finally, the speaker expresses significant optimism for non-invasive (and some invasive) brain stimulation and bioelectric medicine as the next frontier for treating psychiatric disorders and enhancing performance. This approach, which avoids pills and IVs, could become outpatient procedures, offering a new paradigm for intervention.